Influenza virus pathophysiology and brain invasion in mice with functional and dysfunctional Mx1 genes
نویسندگان
چکیده
منابع مشابه
Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene.
The IFN-induced resistance factor Mx1 is a critical component of innate immunity against influenza A viruses (FLUAV) in mice. Animals carrying a wild-type Mx1 gene (Mx1(+/+)) differ from regular laboratory mice (Mx1(-/-)) in that they are highly resistant to infection with standard FLUAV strains. We identified an extraordinary variant of the FLUAV strain, A/PR/8/34 (H1N1) (designated hvPR8), wh...
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چکیده ندارد.
Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background
UNLABELLED Influenza virus infections represent a serious threat to human health. Both extrinsic and intrinsic factors determine the severity of influenza. The MX dynamin-like GTPase 1 (Mx1) gene has been shown to confer strong resistance to influenza A virus infections in mice. Most laboratory mouse strains, including C57BL/6J, carry nonsense or deletion mutations in Mx1 and thus a nonfunction...
متن کاملAssociations of chicken Mx1 polymorphism with antiviral responses in avian influenza virus infected embryos and broilers.
Avian influenza virus (AIV) is a major respiratory disease of poultry that causes catastrophic losses to the poultry industry. The Mx protein has been shown to confer antiviral responses to influenza viruses in mice. One nonsynonymous substitution (S631N) in the chicken Mx protein is reported to be associated with resistance to AIV infection in vitro. The previous studies suggested controversy ...
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ژورنال
عنوان ژورنال: Brain, Behavior, and Immunity
سال: 2012
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2011.07.238